## Graphical Model

Let be the collection of drug names, and be the collection of medical terms for adverse reaction. A drug-adverse reaction relationship is formed as an edge of a bipartite graph between and , and a pair from is called a association candidate if- the induced bipartite subgraph on the pair share at least one edge with the original graph ;
- any smaller pair with and has a fewer edge than .

Report count. The report count of an association candidate can be constructed from the frequency of event.

Marginal count and baseline.

- (marginal count for the list of drugs)
- (marginal count for the list of AE's)

Contingency table. In a similar manner, the conventional contingency table can be obtained from the frequency of event. Here for a pair of individual drug ad AE we can define the cell count

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