be the collection of drug names,
be the collection of medical terms for adverse reaction.
A drug-adverse reaction relationship is formed as an edge
of a bipartite graph
and a pair
is called a association candidate
- the induced bipartite subgraph on the pair
share at least one edge with the original graph ;
- any smaller pair
has a fewer edge than .
The report count of an association candidate
can be constructed from the frequency of event.
the sum is over
as a maximal association candidate.
Marginal count and baseline.
(marginal count for the list of drugs)
(marginal count for the list of AE's)
where the summation
the sum over all the possible association candidate
over all the possible association candidate
Then we can define the baseline
In a similar manner, the conventional contingency table can be
obtained from the frequency of event.
Here for a pair of individual drug ad AE
we can define the cell count
Note that the total number of reporting events
is substantially smaller than the sum of all the cell counts
of the contingency table.
© TTU Mathematics