## Formulas

Listwise and itemwise proportion are estimated from the counts of their respective events:

- (proportion estimate for the list of drugs)
- (proportion estimate for the list of AE's)
- (proportion estimate for the drug )
- (proportion estimate for the AE )

Under the assumption that the reported list of drugs are not associated with the reported list of AE's, the expected counts can be obtained as follows:

- (listwise baseline count for and )
- (itemwise baseline count for and )

Finally relative report rates are formulated as follows:

- (listwise relative report rate for and )
- (itemwise relative report rate for and )

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